Cytokines And B Lymphocytes

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Author: Robin E. Callard
Publisher: Academic Press
ISBN: 0080984320
Size: 75.37 MB
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Cytokines And B Lymphocytes by Robin E. Callard

Original Title: Cytokines And B Lymphocytes

Over the past five years the major importance of cytokines in the regulation of the immune system has become established. This book is the first to review the role of these factors in the control of growth of differentiation of B lymphocytes and thus represents an up-to-date and timely overview of the B-cell response. For the immunologist, there are detailed accounts of the physio-chemical properties of the relevant cytokines and their effect on B lymphocytes from the level of receptor signalling, through ontogeny, activation and proliferation to the expression of specific immunoglobulin isotypes. For the clinician, the involvement of cytokines in disease and normal immune response is discussed.

B Cell Protocols

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Author: Hua Gu (PhD.)
Publisher: Springer Science & Business Media
ISBN: 1592597963
Size: 11.42 MB
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B Cell Protocols by Hua Gu (PhD.)

Original Title: B Cell Protocols

A diverse collection of protocols ranging from the latest inventions and applications to some classic, but still frequently used, methods for studying B-lymphocyte development and function in higher animals. These readily reproducible protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Readily reproducible techniques for studying B-lymphocyte development and function Comprehensive collection of classic and cutting-edge methods Step-by-step instructions that ensure experimental success.

T Lymphocytes Subpopulations In Immunotoxicology

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Author: Ian Kimber
Publisher: John Wiley & Sons
ISBN: 9780471971948
Size: 75.44 MB
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T Lymphocytes Subpopulations In Immunotoxicology by Ian Kimber

Original Title: T Lymphocytes Subpopulations In Immunotoxicology

T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses.

Basic Immunology Updated Edition E Book

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Author: Abul K. Abbas
Publisher: Elsevier Health Sciences
ISBN: 1437726755
Size: 40.55 MB
Format: PDF, ePub, Mobi
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Basic Immunology Updated Edition E Book by Abul K. Abbas

Original Title: Basic Immunology Updated Edition E Book

This updated 3rd edition of Basic Immunology provides a readable and concise introduction to the workings of the human immune system, with emphasis on clinical relevance. The format makes learning easy with short, easy-to-read chapters, color tables, key point summaries, and review questions in every chapter. You’ll get the latest coverage on regulatory T cells, biology of the Th17 subset of CD4+ T cells, and more. The full-color artwork, comprehensive glossary, and clinical cases are just some of the features that reinforce and test your understanding of how the immune system functions. Covers the most up-to-date immunology information including regulatory T cells, and biology of the Th17 subset of CD4+ T cells to keep you completely current. Relates basic science to clinical disorders through clinical cases for better application in a real-world setting. Provides a full Glossary to keep you on the cutting edge of immunologic terminology. Includes appendices summarizing the features of CD Molecules, a handy Glossary, and Clinical Cases that test your understanding of how the immune system functions in health and disease. Presents beautiful full-color artwork for enhanced visual learning.

General And Systematic Pathology E Book

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Author: James C. E. Underwood
Publisher: Elsevier Health Sciences
ISBN: 143772874X
Size: 51.47 MB
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General And Systematic Pathology E Book by James C. E. Underwood

Original Title: General And Systematic Pathology E Book

This highly acclaimed textbook is written specifically for students of medicine and related health science subjects. It progresses from a review of general pathology principles and disease mechanisms through detailed discussions of the pathologic entities associated with each organ system. Nearly 700 full-color photographs and pathology slides bring the content to life. The fifth edition features extensive updates throughout to reflect the latest discoveries in cellular and molecular pathology, and offers a web site that presents self-assessment material and illustrated clinical case studies. Contents perfectly matches needs on medical students. Very clinical approach matches integrated courses. Extensive International Advisory Board validates contents. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers a superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

Fanaroff And Martin S Neonatal Perinatal Medicine

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Author: Richard J. Martin
Publisher: Elsevier Health Sciences
ISBN: 0323295371
Size: 50.15 MB
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Fanaroff And Martin S Neonatal Perinatal Medicine by Richard J. Martin

Original Title: Fanaroff And Martin S Neonatal Perinatal Medicine

Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.

Clinical Applications Of Cytokines And Growth Factors

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Author: John R. Wingard
Publisher: Springer Science & Business Media
ISBN: 9780792384861
Size: 26.49 MB
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Clinical Applications Of Cytokines And Growth Factors by John R. Wingard

Original Title: Clinical Applications Of Cytokines And Growth Factors

The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.

Basic And Clinical Immunology E Book

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Author: Mark Peakman
Publisher: Elsevier Health Sciences
ISBN: 0702042145
Size: 13.91 MB
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Basic And Clinical Immunology E Book by Mark Peakman

Original Title: Basic And Clinical Immunology E Book

Within this one volume both basic science and clinical immunology are demystified for the medical and other health sciences student. The basic immunological processes are described first, with a level of detail restricted to what is appropriate for medical (and similar) curricula. In the second part of the book, immunological mechanisms behind major diseases of the various body systems are explained. Throughout the text clinical details are highlighted and more in-depth material is differentiated from the main text.

Clinical Applications Of Cytokines

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Author: Joost J. Oppenheim
Publisher: Oxford University Press, USA
ISBN: 9780195071290
Size: 31.48 MB
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Clinical Applications Of Cytokines by Joost J. Oppenheim

Original Title: Clinical Applications Of Cytokines

The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.

Molecular Biology Of B Cell And T Cell Development

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Author: John G. Monroe
Publisher: Springer Science & Business Media
ISBN: 147572778X
Size: 59.97 MB
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Molecular Biology Of B Cell And T Cell Development by John G. Monroe

Original Title: Molecular Biology Of B Cell And T Cell Development

Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

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