Mass Spectrometry For Drug Discovery And Drug Development

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Author: Walter A. Korfmacher
Publisher: John Wiley & Sons
ISBN: 1118516141
Size: 13.55 MB
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Mass Spectrometry For Drug Discovery And Drug Development by Walter A. Korfmacher


Original Title: Mass Spectrometry For Drug Discovery And Drug Development

Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

Remington

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Author: David B. Troy
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781746731
Size: 56.98 MB
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Remington by David B. Troy


Original Title: Remington

For over 100 years, Remington has been the definitive textbook and reference on the science and practice of pharmacy. This Twenty-First Edition keeps pace with recent changes in the pharmacy curriculum and professional pharmacy practice. More than 95 new contributors and 5 new section editors provide fresh perspectives on the field. New chapters include pharmacogenomics, application of ethical principles to practice dilemmas, technology and automation, professional communication, medication errors, re-engineering pharmacy practice, management of special risk medicines, specialization in pharmacy practice, disease state management, emergency patient care, and wound care. Purchasers of this textbook are entitled to a new, fully indexed Bonus CD-ROM, affording instant access to the full content of Remington in a convenient and portable format.

Pharmacokinetics In Drug Development

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Author: Peter L. Bonate
Publisher: Springer Science & Business Media
ISBN: 9780971176737
Size: 40.36 MB
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Pharmacokinetics In Drug Development by Peter L. Bonate


Original Title: Pharmacokinetics In Drug Development

These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. Geared toward graduate level students and scientists in the areas of clinical pharmacology and PK, the volumes will fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs, including first-time-in-man, biopharmaceuticals, and special population studies. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Bioanalytical Separations

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Author:
Publisher: Elsevier
ISBN: 9780080527864
Size: 44.84 MB
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Bioanalytical Separations by


Original Title: Bioanalytical Separations

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

New Scientist

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Publisher:
ISBN:
Size: 79.41 MB
Format: PDF, ePub
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New Scientist by


Original Title: New Scientist

New Scientist magazine was launched in 1956 "for all those men and women who are interested in scientific discovery, and in its industrial, commercial and social consequences". The brand's mission is no different today - for its consumers, New Scientist reports, explores and interprets the results of human endeavour set in the context of society and culture.

Biochemical And Biotechnological Applications Of Electrospray Ionization Mass Spectrometry

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Author: A. Peter Snyder
Publisher: Amer Chemical Society
ISBN: 9780841233782
Size: 36.21 MB
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Biochemical And Biotechnological Applications Of Electrospray Ionization Mass Spectrometry by A. Peter Snyder


Original Title: Biochemical And Biotechnological Applications Of Electrospray Ionization Mass Spectrometry

Presents new ways of creating ions of polar and labile biopolymeric species with remarkable ease and efficiency. Introduces better characterization of proteins and other biological molecules. Presents major fundamental issues in such areas as immunology, biochemistry, and natural toxins. Demonstrates methods used to resolve the data from various biological process investigations into useful information. Provides an application-driven approach, presenting valuable insights into the experiments in the volume.

Mass Spectrometry In Drug Metabolism And Pharmacokinetics

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Author: Ragu Ramanathan
Publisher: John Wiley & Sons
ISBN: 111821157X
Size: 69.26 MB
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Mass Spectrometry In Drug Metabolism And Pharmacokinetics by Ragu Ramanathan


Original Title: Mass Spectrometry In Drug Metabolism And Pharmacokinetics

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Mass Spectrometry In Medicinal Chemistry

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Author: Klaus Wanner
Publisher: John Wiley & Sons
ISBN: 352761091X
Size: 22.56 MB
Format: PDF
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Mass Spectrometry In Medicinal Chemistry by Klaus Wanner


Original Title: Mass Spectrometry In Medicinal Chemistry

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

A Handbook Of Bioanalysis And Drug Metabolism

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Author: Gary Evans
Publisher: CRC Press
ISBN: 9780203642535
Size: 44.50 MB
Format: PDF, Kindle
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A Handbook Of Bioanalysis And Drug Metabolism by Gary Evans


Original Title: A Handbook Of Bioanalysis And Drug Metabolism

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

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